Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101
Our cryo-EM structure of p110γ-p101 reveals important differences in the assembly of catalytic and regulatory subunits between class IA and class IB PI3Ks and provides novel insight into PI3K regulation.
Classes of phosphoinositide 3-kinases at a glance - PMC
The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes ...
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 …
2021年8月27日 · The class IB phosphoinositide 3-kinase (PI3K), PI3Kγ, is a master regulator of immune cell function and a promising drug target for both cancer and inflammatory diseases.
Cryo-EM structures of PI3Kα reveal conformational changes ... - PNAS
Here we used single-particle cryoelectron microscopy (cryo-EM) to determine three distinct conformations of full-length PI3Kα (p110α–p85α): the unliganded heterodimer PI3Kα, PI3Kα bound to the p110α-specific inhibitor BYL-719, and PI3Kα exposed to an activating phosphopeptide.
PI3K isoforms in cell signalling and vesicle trafficking
2019年5月20日 · Mammals have eight isoforms of PI3K, divided into three classes. The class I PI3Ks generate 3-phosphoinositide lipids, which directly activate signal transduction pathways.
Diverse activation mechanisms of PI3Ks - Nature
2022年3月7日 · The class II phosphatidylinositol 3-kinases (PI3Ks) serve important roles in diverse cellular processes. The lab of Volker Haucke has now determined high-resolution structures of mouse ...
PI3K signalling: the path to discovery and understanding
2012年2月23日 · Phosphoinositide 3-kinases (PI3Ks) generate intracellular lipids that affect a range of cell biological phenomena. They phosphorylate the 3-OH group of inositol membrane lipids to modulate...
Structure and function of phosphoinositide 3-kinases - PubMed
1998年12月8日 · Proto-Oncogene Proteins p21 (ras) Phosphoinositide kinases (PI3Ks) play an important role in mitogenic signaling and cell survival, cytoskeletal remodeling, metabolic control and vesicular trafficking. Here we summarize the structure-function relationships delineating the activation process of class I PI3Ks involving various domains ….
PIK3IP1: structure, aberration, function, and regulation in diseases
2024年8月15日 · Phosphatidylinoinosidine-3-kinase interacting protein 1 (PIK3IP1), as a unique transmembrane protein, is a newly discovered negative regulator of PI3K pathway. PIK3IP1 negatively regulates PI3K activity by directly binding to the p110 catalytic subunit of PI3K.
The PI3K Pathway in Human Disease - Cell Press
As a central hub for cellular signaling, PI3K is an important regulator of cellular growth and function. This Review focuses on its basic signaling mechanisms as well as its role in metabolism and immune function in the context of cancer.
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