Aerobic glycolysis promotes tumor immune evasion by …
网页2022年9月6日 · Combined treatment with an HK inhibitor and an anti-PD-1 antibody eliminates tumor immune evasion and remarkably enhances the anti-tumor effect of immune checkpoint blockade. These findings elucidate a novel mechanism underlying the upregulation of PD-L1 expression mediated by aerobic glycolysis and underscore the roles of HK2 as a glucose ...
Hexokinase HK3-mediated O-GlcNAcylation of EP300: a key regulator of PD ...
网页2024年8月23日 · Our research identified that the glycolysis-related gene (GRG) HK3 has a unique correlation with PD-L1 expression. HK3 has been identified as a key regulator of O-GlcNAcylation in ccRCC....
Hexokinase II integrates energy metabolism and cellular …
网页2014年10月17日 · Hexokinase catalyzes the phosphorylation of glucose, the rate-limiting first step of glycolysis. Hexokinase II (HK-II) is a predominant isoform in insulin-sensitive tissues such as heart,...
Hexokinase 2 couples glycolysis with the profibrotic actions
网页Yin et al. found that the glycolytic enzyme hexokinase 2 (HK2) was highly abundant in lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and that TGF-β induced the accumulation of HK2 and stimulated glycolysis in mouse and human lung fibroblasts.
Glycolytic enzyme HK2 promotes PD-L1 expression and breast
网页2023年6月12日 · Under high glucose conditions, HK2 acts as a protein kinase and phosphorylates IκBα at T291 in breast cancer cells, leading to the rapid degradation of IκBα and activation of NF-κB, which enters the nucleus and promotes PD-L1 expression.
HK2: Gatekeeping microglial activity by tuning glucose …
网页2023年3月16日 · Hexokinase 2 (HK2) plays a multifaceted role in the regulation of cellular activities. A new study by Hu et al. 1 delineated a critical role of HK2 in governing glycolytic flux and mitochondrial activity, thereby modulating microglial functions in maladaptive inflammation in brain diseases.
网页high glucose-induced PD-L1 expression and promoted CD8+ T cell activation and infiltration into the tumor tissue, reducing brain tumor growth. Combined treatment with an HK inhibitor and an anti-PD-1 antibody eliminates tumor immune evasion and remarkably enhances the anti-tumor effect of immune checkpoint blockade.
Glycolytic enzyme HK2 promotes PD-L1 expression and breast …
网页2023年6月12日 · In this study, we demonstrated that aerobic glycolysis induces PD-L1 expression in an HK2-dependent manner. HK2 phosphorylates IκBα at T291, resulting in IκBα rapid degradation and NF-κB activation, resulting in enhanced PD-L1 transcription and breast cancer cell immune evasion.
Dual roles of hexokinase 2 in shaping microglial function by gating ...
网页2022年12月19日 · Genetic ablation of HK2 reduced microglial glycolytic flux and energy production, suppressed microglial repopulation, and attenuated microglial surveillance and damage-triggered migration in male...
(PDF) Glycolytic enzyme HK2 promotes PD-L1 expression
网页2023年6月12日 · These findings uncover the intrinsic and instrumental connection between aerobic glycolysis and PD-L1 expression-mediated tumor cell immune evasion and underscore the potential to target the...