Electron microscopy of pharmaceutical systems - ScienceDirect
2013年1月1日 · Conventional low-temperature SEM (cryo SEM) was introduced in the 1970s, offering a convenient and rapid sample preparation. The comparatively low resolution was …
Cryogenic Electron Microscopy Methodologies as Analytical Tools …
Cryo-SEM can provide analysis of a fractured frozen specimen by a combination of four detectors: a standard Everhart–Thornley (ET) secondary electron imaging (SEI; “SE2” in the Zeiss lingo) …
Routine High Resolution Cryo SEM Applied to Medical, Cosmetic, …
2020年7月2日 · The value of a Cryo SEM system, attached to a conventional SEM, has already been demonstrated in the biological, pharmaceutical, oil, paint, plastics and food industry. …
Recent advances and current trends in cryo-electron microscopy
2022年12月1日 · Here, we review the latest breakthroughs and current developments of cryo-EM techniques with an emphasis on large molecules using time-resolved methods, natively …
Cryo-EM in drug discovery: achievements, limitations and …
2018年6月8日 · In this article, we describe the recent advances in the field of cryo-EM and critically assess their relevance for drug discovery. We also discuss at what stages of the drug …
Cryo-scanning electron microscopy (cryo-SEM) as a tool for …
2008年3月20日 · In this study, ultrastructural information of internal structure was obtained by imaging the cryo-fractured beads in a cryo-SEM. This technique was found to be excellent for …
Cryo-EM in molecular and cellular biology - Cell Press
2022年1月20日 · This review summarizes the current state of methods and results achievable by cryo-electron microscopy (cryo-EM) imaging for molecular, cell, and structural biologists who …
Characterization of Complex Drug Formulations Using Cryogenic …
2022年4月1日 · Detailed information regarding cryo‐fixation, cryo‐fracture, freeze‐etching, sputter‐coating, and cryo‐SEM imaging is included in this article. A multivesicular liposomal …
Cryo-electron microscopy makes waves in pharma labs - Nature
2017年11月28日 · Companies hope the Nobel Prize-winning imaging methodology will reveal biomolecule characteristics that can guide drug discovery projects. This year's Nobel Prize in …
Characterization of Complex Drug Formulations Using Cryogenic …
2022年4月1日 · This article describes the characterization of complex drug formulations in a frozen‐hydrated state using cryogenic scanning electron microscopy (cryo‐SEM). In …