Biosynthesis of Proline - EcoSal Plus
2007年8月8日 · Proline was among the last biosynthetic precursors to have its biosynthetic pathway unraveled. This review recapitulates the findings on the biosynthesis and transport of proline. Glutamyl kinase (GK) catalyzes the ATP-dependent phosphorylation of L-glutamic acid.
Biosynthesis of Proline - PubMed
Proline was among the last biosynthetic precursors to have its biosynthetic pathway unraveled. This review recapitulates the findings on the biosynthesis and transport of proline. Glutamyl kinase (GK) catalyzes the ATP-dependent phosphorylation of L-glutamic acid.
Mitochondrial NADP+ is essential for proline biosynthesis during …
2021年4月8日 · Cells with NADK2 deletion fail to synthesize proline, due to mitochondrial NADPH deficiency. We uncover the requirement of mitochondrial NADPH and NADK2 activity for the generation of the...
Proline metabolism and redox; maintaining a balance in health …
2021年7月22日 · Proline metabolism at a glance. The three main carbon sources for proline biosynthesis are glucose, glutamine and ornithine, which foster the reactions of PYCR1, 2 and 3/L. Proline and extracellular proline can then be recycled by PRODH during nutrient starvation or metastasis formation.
Mitochondrial NADP(H) generation is essential for proline biosynthesis ...
2021年4月22日 · Proline biosynthesis takes place in the mitochondria, where glutamine-derived glutamate is converted to pyrroline-5-carboxylate (P5C) by pyrroline-5-carboxylate synthase (P5CS). P5C is further reduced to proline by mitochondrial pyrroline-5-carboxylate reductases (PYCR1 and PYCR2) .
Proline-dependent regulation of collagen metabolism - PMC
This review is focused on recent data on the role of proline (Pro) in collagen biosynthesis and cellular metabolism. It seems obvious that one of the main substrates for collagen biosynthesis Pro is required to form collagen molecule.
Proline and hydroxyproline metabolism: implications for animal …
Proline plays important roles in protein synthesis and structure, metabolism (particularly the synthesis of arginine, polyamines, and glutamate via pyrroline-5-carboxylate), and nutrition, as well as wound healing, antioxidative reactions, and immune responses.
Evolution of proline biosynthesis: enzymology, bioinformatics, …
Proline is not only an essential component of proteins but it also has important roles in adaptation to osmotic and dehydration stresses, redox control, and apoptosis. Here, we review pathways of proline biosynthesis in the three domains of life.
The Multifaceted Roles of Proline in Cell Behavior - PMC
Proline is an organocatalyst used to synthesize enantiopure drugs (middle top). Proline is also a potent chemical chaperone able to stabilize proteins in their natural conformation and thus, it is used to cryopreserve living cells/organisms (middle bottom).
Mitochondrial NADPH is a pro at Pro synthesis | Nature Metabolism
2021年4月8日 · These important insights uncover a major role of mitochondrial NADPH in proline biosynthesis and suggest that cancers will be more dependent on NADK2 in proline-depleted environments.
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