Prostratin: An Overview - PubMed
网页Prostratin [13-O-acetyl-12-deoxyphorbol] is a phorbol ester that was first isolated from Strathmore weed Pimelea prostrate, a small endemic New Zealand shrub, and characterized by Hecker in 1976.
Prostratin - an overview | ScienceDirect Topics
网页Originally discovered in the 1970s in species of Pimelia (Thymelaceae) which had proved toxic to livestock in New Zealand and Australia, Prostratin was again isolated in the mid-1980s from Homalanthus nutans in Samoa.
Total Synthesis of Prostratin, a Bioactive Tigliane Diterpenoid: …
网页2020年3月13日 · This account details the development of a modular and concise synthesis of prostratin, a potent anti-HIV and anticancer agent. The key approach in this synthesis involved a sequence of oxidative dearomatization and sequential stereoselective installation of peripheral groups to rapidly build the contiguously substituted cyclohexane C-ring.
Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant ...
网页2008年5月2日 · Prostratin (3, 12-deoxyphorbol-13-acetate) and DPP (4, 12-deoxyphorbol-13-phenylacetate) are non–tumor-promoting 12-deoxytigliane diterpenes that exhibit potent in vitro activity in inducing HIV expression in latently …
Total Synthesis of (±)-Prostratin: Chem - Cell Press
网页2018年12月13日 · Prostratin itself is a promising lead for developing a long-sought-after cure for human immunodeficiency virus (HIV) infection and an anti-cancer drug. In this work, we report a short and modular synthetic route to prostratin from very simple chemicals.
Dual Role of Prostratin in Inhibition of Infection and Reactivation …
网页2004年1月8日 · Prostratin is an activator of protein kinase C and a potent antitumor agent that directly blocks tumor promotion by phorbol-12-myristate-13-acetate (TPA). Prostratin was originally extracted from the Samoan medicinal plant Homalanthus nutans and has been described as a drug that inhibits HIV replication and cell killing in vitro (24, 25, 30).
An overview of the traditional use, phytochemistry, and biological ...
网页2023年4月1日 · The most promising compound is prostratin, isolated from H. nutans, with anti-HIV activity and the ability to eradicate the HIV reservoir in infected patients by mechanism of protein kinase C (PKC) agonist.
Prostratin: activation of latent HIV-1 expression suggests a …
网页2001年11月15日 · Prostratin is a unique phorbol ester that stimulates protein kinase C activity but is nontumor promoting. Remarkably, prostratin is also able to inhibit de novo human immunodeficiency virus type 1 (HIV-1) infection yet up-regulate viral expression from latent proviruses.
Prostratin: An Overview | Bentham Science
网页2022年12月31日 · Prostratin [13-O-acetyl-12-deoxyphorbol] is a phorbol ester that was first isolated from Strathmore weed Pimelea prostrate, a small endemic New Zealand shrub, and characterized by Hecker in 1976.
Prostratin: An Overview. - Abstract - Europe PMC
网页2015年1月1日 · Prostratin [13-O-acetyl-12-deoxyphorbol] is a phorbol ester that was first isolated from Strathmore weed Pimelea prostrate, a small endemic New Zealand shrub, and characterized by Hecker in 1976.
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