Protease mechanisms | Learn Science at Scitable - Nature
Protease mechanisms. Polypeptides can be cleaved either chemically or enzymatically. Enzymes that catalyse the hydrolytic cleavage of peptide bonds are called proteases. Proteases fall into …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable - Nature
2010年8月24日 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and …
Proteases - Latest research and news - Nature
2024年11月8日 · Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove …
Human and mouse proteases: a comparative genomic approach
2003年7月1日 · For each single protease locus, a 500-kb genomic sequence flanking the target gene was analysed for the presence of further members of that family, as ∼ 23% of human …
Mapping specificity, cleavage entropy, allosteric changes and
2021年3月16日 · Proteolytic cleavage by proteases is a common protein posttranslational modification and a mechanism that regulates protein functions. It is crucial for cellular health …
On the cutting edge: protease-based methods for sensing and
2020年7月13日 · Protease-based systems essentially use one of two mechanisms to sense upstream events: proximity-induced fragment complementation (of protease or, in the case of …
A novel alkali and thermotolerant protease from Aeromonas spp
2024年10月29日 · Protease enzymes, in particular, have proven to be cost-effective, stable, and compatible alternatives to traditional chemical processes in both industrial and environmental …
New roles for mitochondrial proteases in health, ageing and …
2015年5月13日 · Using information from protease databases Degradome 10 and MEROPS 11, together with data from MitoCarta, which is an inventory of mammalian mitochondrial proteins …
Targeting proteases: successes, failures and future prospects
Proteases, also known as proteolytic enzymes, are enzymes that catalyse the breakdown of proteins by hydrolysis of peptide bonds. Using bioinformatic analysis of the mouse and human …
Substrate specificity of the ubiquitin and Ubl proteases
2016年3月25日 · An interesting example of the challenges in predicting Ubl protease substrate specificity comes from a study of XopD, a C48 Ulp1-like protease derived from a plant …