RAGE-mediated cell signaling - PubMed
RAGE signaling has been mainly studied as a pathogenetic factor of several diseases, where acute or chronic inflammation plays a role. Recent studies have suggested a physiological role for RAGE in normal lung function and in neuronal signaling.
RAGE regulation and signaling in inflammation and beyond
2013年3月29日 · In this review, we will summarize the role of RAGE in the establishment and sustainment of an inflammation, the impact of RAGE signaling in the different types of leukocytes, and the current knowledge about the components of these signal pathways.
Receptor for AGE (RAGE): signaling mechanisms in the …
AGEs, largely via RAGE, activate signaling mechanisms that cause cell stress, contribute to cellular dysfunction, and damage target organs, leading to complications.
Activation and modulation of the AGEs-RAGE axis: Implications for ...
2024年8月1日 · By binding to RAGE, AGEs activate signaling pathways such as NF-κB, promoting the release of inflammatory factors, exacerbating cell damage and inflammation, and further advancing the formation of atherosclerotic plaques and tumor development.
Targeting RAGE Signaling in Inflammatory Disease
Blocking RAGE signaling in cell and animal models has revealed that targeting RAGE impairs inflammation and progression of diabetic vascular complications, cardiovascular disease (CVD), and cancer progression and metastasis.
Pathophysiology of RAGE in inflammatory diseases - Frontiers
2022年7月28日 · AGEs induce pathological processes through three main mechanisms: first, by altering the structural features of proteins through the formation of crosslinks; second, by interacting with their receptor RAGE, which activates downstream signaling pathways leading to increased production of reactive oxygen species and inflammatory cytokines; and thi...
RAGE is a PRR and central mediator of the innate immune response. RAGE is also expressed on T and B lymphocytes [1– 4], as well as on DCs [5–7], representing a new link between the innate and adaptive immune system. Activation of RAGE is involved in the immediate inflammatory response.
RAGE signaling in inflammation and arterial aging - PubMed
2009年1月1日 · The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor (PRR) that interacts with diverse endogenous ligands. Ligation of RAGE triggers a series of cellular signaling events, including the activation of transcription factor NF-kappaB, leading to the production of pr ….
Role and therapeutic potential of RAGE signaling in …
Activation of the receptor for advanced glycation end products (RAGE) has been shown to play an active role in the development of multiple neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis.
Pathophysiology of RAGE in inflammatory diseases - PubMed
2022年7月29日 · The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand pattern recognition receptor capable of binding to a range of structurally diverse ligands, expressed on a variety of cell types, and performing different functions.
- 某些结果已被删除