Human sebum requires de novo lipogenesis, which is increased in acne …
2019年5月15日 · Excess sebum production contributes to the pathogenesis of acne vulgaris, and suppression of sebum production reduces acne incidence and severity. We demonstrate that sebum production in humans depends on local flux through the de novo lipogenesis (DNL) pathway within the sebocyte.
Lipidomics of facial sebum in the comparison between acne and non-acne ...
2021年8月16日 · Sebum incretion in acne was paralleled by significantly higher abundance of triglycerides, wax esters, and squalene together with monounsaturated FAs (MUFAs), and straight chain saturated...
Smart skin bacteria are able to secrete and produce molecules to treat acne
2024年1月9日 · An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without ...
Sebum analysis of individuals with and without acne - PMC
In the current study we investigated differences in sebum composition between males, 15–20 years old, with no acne, or with severe acne. All of the healthy controls (no acne) subjects declared that they had acne 1–3 years ago.
The grease trap: uncovering the mechanism of the hydrophobic …
2020年5月1日 · When the excess sebum forms a plug in the follicle, C. acnes in the follicle digests sebum, creating inflammation and leading to papules, pustules, nodules, or cysts. C. acnes is a normally harmless bacteria, but recent studies have revealed that the proportion of C. acnes strains, not the population of bacteria, changes between healthy and ...
Regulation of Human Sebaceous Glands - ScienceDirect
2004年7月1日 · The pathogenesis of acne centers on the interplay of: 1) sebum production by the sebaceous gland; 2) colonization of the hair follicle by Propionibacterium acnes, 3) hyperkeratinization of the upper follicle; and 4) the release of …
Inhibiting sebum production to treat acne - Nature
2019年6月5日 · Writing in Science Translational Medicine, Esler and colleagues now demonstrate that human sebum production is highly dependent on sebocyte de novo lipogenesis (DNL) and flux through this...
Impact of skin sensitivity mechanisms on sebum secretion: …
2024年6月1日 · When exploring the mechanisms underlying sebum secretion in oily sensitive skin, one key biochemical pathway emerges. Regardless of the triggering stimulus or activation pathways involved in increased sebum production, all known mechanisms converge on the first rate-limiting step in fatty acid synthesis.
Delivery of a sebum modulator by an engineered skin microbe in …
2024年1月9日 · Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum...
Rethinking Sebum and Its Role in Acne - PracticalDermatology
2022年6月20日 · The different composition of sebum in patients with acne compared to those without acne is essential to understanding the pathogenesis of acne. This helps explain the differences between oily and acne-prone individuals and can help us better treat patients using therapeutics and cosmetic products that address the specific needs of the skin in ...
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