Cellular senescence in gastrointestinal diseases: from ... - Nature
2017年11月29日 · In this Review, we provide an introduction to cellular senescence, addressed particularly to gastroenterologists and hepatologists, and discuss the implications of senescence for the...
Senescent cells perturb intestinal stem cell differentiation through ...
2023年1月11日 · Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue...
Multiple pathways promote microtubule stabilization in senescent ...
2022年12月16日 · Microtubules control epithelial functions, and we identified microtubule stabilization as a phenotypic marker of senescent intestinal epithelial cells. The senescence inducer determined the...
Age-related morphological and functional changes in the small intestine ...
2022年6月15日 · In particular, to understand how senescence affects the small intestine, we investigated whether age-related changes in the morphology of the intestinal villi and its capability to digest/absorb nutrients are associated with the senescence phenotypes identified in …
Senolytic CAR T cells reverse aging-associated defects in intestinal ...
2024年3月19日 · As a first step to investigate the presence of senescent cells accumulated during physiological aging in the small intestine we performed senescence-associated beta-galactosidase staining (SA-β-gal) in the proximal jejunum of young (3 months old) and old (20 months old mice) and found a significant increase in the number of SA-β-gal + cells ...
Multiple pathways promote microtubule stabilization in senescent ...
2022年12月16日 · Microtubules control epithelial functions, and we identified microtubule stabilization as a phenotypic marker of senescent intestinal epithelial cells. The senescence inducer determined the pathway to microtubule stabilization.
Senescent cells and macrophages cooperate through a multi …
2024年3月11日 · During intestinal transformation, concurrent activation of AKT, DDR, and JNK signaling triggers senescence in a small number of cells. Senescent-cell-driven Mmp1 expression disrupts the basement membrane, resulting in the recruitment of phagocytic hemocytes, which express the JNK pathway ligand Eiger.
Senolytic Treatment Improve Small Intestine Regeneration in Aging
Senolytic alleviate senescence of small intestine. To investigate the impact of D+Q on small intestine in aging, we collected jejunum from 3-month-old mice and 16-month-old mice treated with/without D+Q .
Cellular Senescence, Inflammation, and Cancer in the ... - MDPI
2023年6月6日 · Cellular senescence causes cells to undergo cell cycle arrest, at which point the cells are no longer able to grow and replicate but remain metabolically active so as to affect normal cells both locally and systemically [12]. It is an important defense mechanism against DNA damage, telomere destruction, and other stressors.
B cell senescence takes guts | Nature Cell Biology
2023年5月24日 · By single-cell RNA sequencing, the authors identified a population of p16 -expressing activated B cells in germinal centres within the small intestine of aged mice. This B cell population...