Precision Technique for Splenectomy Limits Mouse Stress
网页2019年8月5日 · Abstract. Splenectomy in an animal model requires a standardized technique utilizing best practice to avoid variability which can result in adverse impact to the animal resulting in flawed physiologic responses simply due to technique rather than to the studied variables.
Precision Technique for Splenectomy Limits Mouse Stress …
网页2019年8月5日 · We describe a step by step technique for splenectomy with emphasis on performing a quick and easy surgery by limiting the length of the operation and being familiar with mouse anatomy and some techniques to limit …
Splenectomy modulates early immuno-inflammatory responses …
网页2018年10月5日 · We investigated the impact of splenectomy on immune responses in the 1st-hit polytrauma alone and on survival in the post-traumatic sepsis (2nd hit). Female BALB/c mice underwent polytrauma...
Splenectomy does not affect mouse behaviors - PMC - National …
网页2022年11月9日 · This preliminary work demonstrates that splenectomy has no significant effect on the behavior of mice, under either non-stimulating or CUMS-stimulating conditions. This conclusion supports the application of the splenectomy mouse model in research involving brain behavior and immunity.
Splenectomy modulates the immune response but does not …
网页2022年5月16日 · Splenectomy did not abrogate the development of the recombinant-human G1 (rhG1) domain-induced arthritis (GIA) in mice. However, the immune response was modified in the absence of the spleen: the mesenteric and inguinal lymph nodes (m/iLN) showed activation after the immunization with rhG1.
Splenectomy does not affect mouse behaviors - PubMed
网页Splenectomy did not induce changes in general locomotion, circadian rhythms, learning and memory, or depression/anxiety-related behaviors. To further investigate the effects of spleen on stress susceptibility, we established mouse models of depression through chronic unpredictable mild stress.
Splenectomy has opposite effects on the growth of primary
网页2024年2月24日 · Splenectomy decreased the frequency of natural killer (NK) cells in the peripheral blood of LuM1 tumor-bearing mice. Using flow cytometry, we calculated the ratios of T cells and NK cells in...
The compensatory role of T cells from lymph nodes in mice with splenectomy
网页2024年5月21日 · To further investigate the impact of splenectomy on T cell immunity to infection, we infected sham mice and splx mice with 1 × 10 6 CFU of LM-GP33 2 weeks after surgery (Figure 2A). We found that mice that underwent splenectomy showed an increased survival rate during primary infection (Figure 2B ).
Splenectomy protects aged mice from injury after experimental …
网页We investigated the contribution of spleen to brain injury after cerebral ischemia in aged male mice. Splenic architecture and immune cell composition were altered in aged mice. Splenectomy 2 weeks before stroke resulted in improved neurobehavioral and infarct outcomes in aged male mice.
Effects of splenectomy on skin inflammation and psoriasis-like
网页2022年8月30日 · This is the first study to show how the spleen contributes to psoriasis-like phenotypes in IMQ-treated mice. Indeed, topical application of IMQ significantly increased infiltration of immune...