CD134 - Wikipedia
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28.
TNFRSF4 Gene - GeneCards | TNR4 Protein | TNR4 Antibody
2024年10月2日 · TNFRSF4 (TNF Receptor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include Immunodeficiency 16 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
又一热门靶点（OX40）被详细解读 - 知乎 - 知乎专栏
OX40 (CD134, TNFRSF4) 最初被定义为T细胞活化标记物，后发现是具有共激活功能的NGFR/TNFR超家族成员。. OX40基因位于人1号染色体（小鼠4号染色体），编码一种50kD的一型跨膜糖蛋白。. 胞外区有191个氨基酸，包含了三个完整的以及一个稍短的富含半胱氨酸结构 …
OX40/OX40L：癌症及自免疫明星靶点 - 知乎 - 知乎专栏
2024年1月17日 · ox40又叫做cd134、act35、tnfrsf4，于1987年首次在激活的老鼠cd4+ t细胞上被发现，属于tnfr超家族的一员。 ox40基因和其它几个tnfr家族的分子(tnfr2, 4-1bb, hvem, cd30, gitr, dr3)成簇的排列在人的1号染色体上。
Tnfrsf4-expressing regulatory T cells promote immune escape …
2021年12月8日 · BM Tregs in CML were characterized by the selective expression of tumor necrosis factor receptor 4 (Tnfrsf4). Stimulation of Tnfrsf4 signaling did not deplete Tregs but reduced the capacity of Tregs to protect LSCs from CD8+ CTL-mediated killing.
Single-cell profiling of immune cells after neoadjuvant ... - Nature
2022年7月13日 · Anti-TNFRSF4 antibody augmented antitumor immunity in animal models with several types of cancers, and the anti-tumor effects were mainly dependent on the reduction of Treg...
Identification and validation of TNFRSF4 as a high-profile …
2022年5月13日 · Highlighted by TNFRSF4, we found that it was not only positively correlated with the TICs (mainly CD4+ T cells, CD8+ T cells, and Tregs) but significantly related to the prognosis in patients of EC, both verified by data from The Cancer Genome Altas (TCGA)-EC database and clinical samples.
TNFRSF4 TNF receptor superfamily member 4 [ (human)]
OX40 ligation on CD4 (+) T cells represents a potentially novel immunotherapeutic strategy that should be investigated to treat and prevent persistent virus infections, such as HIV-1 infection. The protein encoded by this gene is a member of the TNF-receptor superfamily.
Tumour heterogeneity and intercellular networks of ... - Nature
2021年2月2日 · Trajectory analyses reveal exhausted CD8 + T and immune-suppressive TNFRSF4 + Treg cells in tumours might derive from peripheral CX3CR1 + CD8 + T and naïve Treg cells, respectively. Moreover, we...
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 …
2024年9月18日 · Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [ (house mouse)] Gene ID: 22163, updated on 18-Sep-2024. Summary. Enables tumor necrosis factor-activated receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression.