What Are Translocations? What Disorders Do They Cause? - WebMD
2022年7月21日 · A translocation chromosome mutation can be of two types — reciprocal and Robertsonian. In a reciprocal translocation, two different chromosomes have exchanged pieces with each other.
Translocation: Types, Causes, and Related Conditions - Verywell …
2023年6月28日 · Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes . When translocation occurs, it causes flaws in chromosomes, which can lead to serious genetic and health conditions like cancer.
Translocation - National Human Genome Research Institute
4 天之前 · A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of chromosomal translocations can be important for the diagnosis of …
Chromosomal translocation - Wikipedia
Chromosomal reciprocal translocation of the 4th and 20th chromosome. In genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal, and Robertsonian translocation.
The biogenesis of chromosome translocations - PMC
Chromosome translocations are catastrophic genomic events and often play key roles in tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly understood. Recent work has delineated several distinct mechanistic steps in ...
Human Chromosome Translocations and Cancer - Nature
Cytogeneticists have identified thousands of different translocations, may of which have been linked to aneuploidy, infertility, and cancer.
Mechanisms driving chromosomal translocations: lost in time …
2021年6月8日 · Increased translocations can thus be linked to a break down in temporal restrictions to translocation, due to the association of translocation with high levels of breakage and delayed repair.
Unbalanced translocations arise from diverse mutational …
Thirteen translocations do not disrupt a gene at either chromosome breakpoint, and 32 translocations disrupt a gene at one but not both breakpoints. In six simple translocations, both breakpoints lie in the open reading frame of genes.
Mechanisms driving chromosomal translocations: lost in time and …
Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it is important to understand the mechanisms leading these chromosome rearrangements.
Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it...