The vacuolization of macrophages induced by large amounts of …
2019年12月21日 · We hypothesize that vacuoles are formed in large amounts during NP uptake by macrophages, which enhances the immune response and induces macrophages toward M1 polarization. These findings are potentially useful for disease treatment and understanding the immune response when NPs are used in vitro and in vivo.
Barrier-tissue macrophages: functional adaptation to ... - Nature
2017年11月7日 · Macrophages are sessile mononuclear cells found in all tissues of the body, where they appear as large vacuolated cells with abundant cytoplasm containing lysosomal granules. Classically,...
Cytoplasmic vacuolation, adaptation and cell death: A view on …
1999年9月1日 · Vacuoles developed within 2-3 h in the perinuclear region and occupied > 25% of the cytoplasmic volume. Similar data are found in Ohkuma and Poole (1981), following treatment of mouse peritoneal macrophages with chloroquine and other weakly basic substances.
The panorama of different faces of mesothelial cells - PMC
Vacuolated mesothelial cells with macrophage features (pleural fluid). Panorama of cytomorphologic features with central to slightly eccentric nuclei. [a–l, DQ-stained cytospin smears (a–l, 100X zoomed).] However, mesothelial cells with some features of macrophages may resemble malignant cells.
Vacuolated macrophage with digested cells, bone marrow …
2020年11月16日 · Images A and B present vacuolated macrophages with digested cells inside phagosomes. Phagosomes fuses with lysosomes to complete the digestion process. Download Image
Immune complex-driven generation of human macrophages with …
To maintain homeostasis, macrophages must be capable of assuming either an inflammatory or an anti-inflammatory phenotype. To better understand the latter, we stimulated human macrophages in vitro with TLR ligands in the presence of high-density immune complexes.
Macrophages in cardiovascular diseases: molecular mechanisms …
2024年5月31日 · In this review, we systematically summarize the diverse phenotypic and functional plasticity of macrophages in regulatory mechanisms of cardiovascular diseases and unprecedented insights...
Cytoplasmic vacuolation of mouse peritoneal macrophages and …
When the concentration within the lysosomes becomes sufficiently high, osmotic swelling occurs. The cells than take on a vacuolated appearance. The concentrations at which different weak bases cause lysosomal vacuolation vary over almost three orders of magnitude.
macrophages residing within the marrow and splenic macrophages facilitate the generation and elimination of new and dying red blood cells. Whether it be in the CNS, where microglia coop-eratively function within neurovascular units, or in the periphery, where perivascular and cardiac macrophages support vascular integrity, RTMs
PAS-positive macrophages—not always infection - The Lancet
2011年5月28日 · A bone-marrow biopsy sample showed infiltration of foamy, vacuolated macrophages with granules positive for periodic-acid-Schiff (PAS) (figure). The material was also highlighted by a Grocott silver stain, which raised the suspicion of histoplasmosis, and he was treated with itraconazole.