Aconitine - Wikipedia
网页Aconitine is an alkaloid toxin produced by various plant species belonging to the genus Aconitum (family Ranunculaceae), commonly known by the names wolfsbane and monkshood. Aconitine is notorious for its toxic properties.
Aconitine: A review of its pharmacokinetics, pharmacology, …
网页2022年7月15日 · Results: In this review, we address the pharmacokinetics of aconitine, as well as its pharmacological effects including anti-cancer, anti-inflammatory, anti-virus, immunoregulation, analgesic, insecticide and inhibition of androgen synthesis.
乌头碱 - 百度百科
网页乌头碱，是一种双酯类生物碱，化学式为C34H47NO11，有剧毒，它主要使迷走神经兴奋，对周围神经损害。.
Aconitine - an overview | ScienceDirect Topics
网页2018年8月6日 · Aconitine is a highly toxic compound produced by the Aconitum plant, commonly known as monkshood. It is used in ancient medicines and was historically used to make poisoned arrows. Aconitine acts by opening sodium channels, preventing repolarization of muscles and neurons, leading to ventricular dysrhythmia and …
Aconitine and its derivatives: bioactivities, structure-activity ...
网页2024年1月22日 · Aconitine (AC), which is the primary bioactive diterpene alkaloid derived from Aconitum L plants, have attracted considerable interest due to its unique structural feature. Additionally, AC demonstrates a range of biological activities, such as its ability to enhance cardiac function, inhibit tumor growth, reduce inflammation, and provide ...
Aconitine: A review of its pharmacokinetics, pharmacology, …
网页2022年7月15日 · The objectives of the review are i) to summarize the pharmacokinetics of aconitine, ii) to update the latest advances about the pharmacological and toxicological effect of aconitine, and iii) to discuss detoxification and some promising direction for further research on aconitine.
乌头碱 - 维基百科，自由的百科全书
网页2024年6月16日 · 乌头碱 （英语： aconitine）是一种 生物碱 毒素。 是常用 中药 乌头属 中所含有的一种化学物质，具强烈毒性,口服0.2mg左右即能使人中毒，3-5mg即可致死。 [1] 民间常用草乌、川乌等植物来泡制药酒，但这种药酒可能是极端危险的，也经常因此出现中毒甚至死亡的情况。 [2][3] 用途. [编辑] 乌头碱以前被用作 解热药 和 镇痛药，但在 草药 中的应用仍然有限。 狭窄的 治疗指数 使计算合适的剂量很困难。 [4] 结构和反应性. [编辑] 附子属 …
An insight into current advances on pharmacology, …
网页2022年7月1日 · Recent studies have shown that aconitine significantly inhibited the proliferation of EC-1 cells in esophageal cancer with time and dose effects. Aconitine exerted its anti-tumor effect significantly by reducing the colony formation and cell invasion, and down-regulating the expression of MMP-9 and Bcl-2 [27].
Advances on pharmacology and toxicology of aconitine
网页Aconitum alkaloids are considered to be the characteristic bioactive ingredients of Aconitum species, which are widely applied to the treatment of diverse diseases, and aconitine (AC) is found in most Aconitum plants. Research evidence shows that low-dose AC has a good therapeutic potential in heart failure, myocardial infarction ...
Cardiac efficacy and toxicity of aconitine: A new frontier for the ...
网页2021年1月29日 · Aconitine (AC) is well-known as the main toxic ingredient and active compound of Aconitum species, of which several aconites are essential herbal medicines of Traditional Chinese Medicine (TCM) and widely applied to treat diverse diseases for their excellent anti-inflammatory, analgesic, and cardiotonic effects.