Aggrecan - Wikipedia
Aggrecan is a high molecular weight (1x10 6 < M < 3x10 6) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are attached to an extended protein core.
Structure and function of aggrecan | Cell Research
2002年3月1日 · Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for ...
The role of aggrecan in normal and osteoarthritic cartilage
Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads. It is present in the extracellular matrix in the form of proteoglycan aggregates, in which many aggrecan molecules interact with hyaluronan and a link protein stabilizes ...
2002年1月22日 · Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for ...
Aggrecan: Beyond cartilage and into the brain - ScienceDirect
2012年5月1日 · Aggrecan protein (also known as AGC1, CSPG1, CSPCP, and CSPGCP) encoded by the gene ACAN is a chondroitin sulphated proteoglycan (CSPG) that is a critical structural component of cartilage. Aggrecan is the founding member of a family of CSPGs called the lecticans (for review see Viapiano and Matthews, 2006).
Aggrecan: a new biomarker for acute type A aortic dissection
2021年5月14日 · Aggrecan (ACAN) is a multimodular proteoglycan which can make up to 10% of the cartilage 13 ACAN plays a major role in bone and cartilage morphogenesis and several mutations have been...
硫酸軟骨素蛋白聚醣 - 维基百科，自由的百科全书
硫酸軟骨素蛋白聚糖 （英語： chondroitin sulfate proteoglycan，CSPGs）又稱 硫化軟骨蛋白聚醣，是 硫酸软骨素 與 蛋白聚醣 結合的產物，在 腦部 中調控 神經系統 的發育與生長，它能抑制神經纖維的再生。.
Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, …
2020年8月27日 · This review examines aggrecan's roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues. Aggrecan is a remarkably versatile and capable proteoglycan (PG) with diverse tissue context-dependent functional attributes beyond its estab ….
Aggrecan: Approaches to Study Biophysical and Biomechanical …
Aggrecan, the most abundant extracellular proteoglycan in cartilage (~35% by dry weight), plays a key role in the biophysical and biomechanical properties of cartilage. Here, we review several approaches based on atomic force microscopy (AFM) to probe the physical, mechanical, and structural properties of aggrecan at the molecular level.
Aggrecan in Cardiovascular Development and Disease
2020年9月1日 · Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of …
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