Mannan-binding lectin - Wikipedia
MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. Although MBL can form several oligomeric forms, there are indications that dimers and trimers are biologically inactive as an opsonin and at least a tetramer form is needed for activation of complement.
Mannose-Binding Lectin: Biologic Characteristics and Role in the ...
Introduction. The mannose-binding lectin (MBL) is a protein of the innate immune system, belonging to the collectin family, able to deploy a variety of antimicrobial activities. It recognizes and binds various pathogens (including bacteria, viruses, fungi, and parasites), providing protection against the microbial invasion of the host [1].
Mannan-binding lectin: structure, oligomerization, and flexibility ...
2009年8月7日 · Mannan-binding lectin (MBL) is the archetypical pathogen recognition molecule of the innate immune defense. Upon binding to microorganisms, reactions leading to the destruction of the offender ensue. MBL is an oligomer of structural subunits each composed of …
The Lectin Pathway of the Complement System—Activation, …
Mannose-binding lectin (MBL), other collectins, and ficolins are collectively termed as the pattern recognition molecules (PRMs) of the LP, and they are responsible for targeting LP activation to molecular patterns, e.g., on bacteria.
Mannose-Binding Lectin in Human Health and Disease
2021年3月13日 · Mannose-binding lectin (MBL) plays, as a soluble pattern recognition molecule, a central role in the innate immune response. MBL binds to the surface of carbohydrates on a wide variety of pathogens and mediates opsonophagocytosis via activation of the lectin...
Mannan Binding Lectin - an overview | ScienceDirect Topics
Mannan-binding lectin (MBL) is an oligomeric lectin (based on a homotrimeric structural unit) which recognizes neutral sugars (mannose and N -acetylglucosamine) on microbial surface and is involved in innate immunity against infection. Serum purified MBL is a mixture of oligomers with two major forms: MBL-I and MBL-II.
Tackling the Legs of Mannan-Binding Lectin: Structure - Cell Press
2011年11月9日 · In the lectin and classical pathways, complement is triggered upon recognition of a pathogen by an activating complex. Here we present the first structure of such a complex in the form of the collagen-like domain of mannan-binding lectin (MBL) and the binding domain of its associated protease (MASP-1/-3).
Mannose-binding lectin and its genetic variants | Genes
2006年1月5日 · Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of the complement system and is of importance for host defence. Common variant alleles situated both in...
Mannan-binding lectin: clinical significance and applications
2002年9月19日 · Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin domains) synthesised in the liver and secreted into the bloodstream. Its plasma concentration is for the most part genetically determined by a series of allelic dimorphisms located both in the structural gene and in the promoter region.
Mannan-Binding Lectin: Structure, Oligomerization, and …
2009年8月7日 · Mannan-binding lectin (MBL) is the archetypical pathogen recognition molecule of the innate immune defense. Upon binding to microorganisms, reactions leading to the destruction of the offender ensue. MBL is an oligomer of structural subunits each composed of …
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