Ulinastatin - Wikipedia
Ulinastatin is an acid-resistant protease inhibitor found in human urine and released from the high-molecular-weight precursor I alpha T1. It inactivates many serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, …
Ulinastatin, a Urinary Trypsin Inhibitor, for the Initial Treatment …
2011年11月21日 · Ulinastatin (UTI), a urinary trypsin inhibitor that protects tissues and organs against neutrophil-mediated injury, is considered to be a reasonable treatment of KD because several investigations have demonstrated that markedly activated neutrophils or higher plasma levels of neutrophil elastase are involved in the poor response to IVIG and the ...
Ulinastatin is effective in reducing mortality for critically ill ...
2018年9月25日 · Ulinastatin has been found to have anti-inflammatory effect for patients with sepsis. However, its clinical effects were conflicting. The study aimed to investigate the cost-effectiveness of...
Ulinastatin - a newer potential therapeutic option for ... - PubMed
Ulinastatin also suppresses the activation of PMN cells, macrophages, and platelets. Derived from these properties, ulinastatin has been investigated as a potential clinical therapy for indications including shock and pancreatitis and approved in Japan and China with ongoing clinical trials around the globe.
Improvement of Sepsis Prognosis by Ulinastatin: A Systematic ... - PubMed
2019年11月26日 · Conclusions: Ulinastatin improved all-cause mortality and other related outcomes in patients with sepsis or septic shock. The results of this meta-analysis suggest that ulinastatin may be an effective treatment for sepsis and septic shock. Keywords: immune system; inflammatory cytokine; mortality; sepsis; ulinastatin.
The combination of ulinastatin and somatostatin reduces …
2022年10月26日 · Ulinastatin in combination with somatostatin analogue decreases rates of: (a) MODS, (b) AKI, and (c) ARDS, but not of (d) shock, compared to somatostatin analogue monotherapy when administered...
Ulinastatin: A Potential Alternative to Glucocorticoid in the …
2020年3月26日 · Ulinastatin (UTI), a potent anti-inflammatory agent, has been used clinically, including as a substitution for steroids. This study aimed to explore the potential effects of UTI upon DCS in a rabbit model. Eighty-eight rabbits were subjected to simulated diving to 6 atmospheres absolute (ATA) for 60 min with 2.5-minute decompression.
Ulinastatin treatment for acute respiratory distress syndrome …
2019年11月4日 · Currently, ulinastatin is a glycoprotein that acts as a protease inhibitor and has been used to treat ARDS [11, 12], pancreatitis [13], multi-organ failure [14] and sepsis [15] in Asia for several years. A summary of the potential mechanisms accounting for the effects of ulinatistin in ARDS is shown in Table 1.
Xuebijing combined with ulinastation benefits patients with sepsis…
2018年3月1日 · Introduction. Sepsis refers to systemic inflammation caused by infection response syndrome, and it is a common complication of severe trauma, burn, shock, major surgical operation in critically ill patients and is also one of the major causes of shock, multiple organ dysfunctions and organ failure in patients [1].
Use of ulinastatin was associated with reduced mortality in …
2019年5月3日 · Ulinastatin is a serine protease inhibitor found in the blood and urine of humans. Animal studies have demonstrated anti-inflammatory effects of ulinastatin ( 7, 8) and identified potential benefits for the management of multiple organ dysfunction induced by sepsis ( 9 ).